The MS Delta NHA includes 18 counties that contain land located in the alluvial floodplain of the Mississippi Delta: Bolivar, Carroll, Coahoma, DeSoto, Holmes, Humphreys, Issaquena, Leflore, Panola, Quitman, Sharkey, Sunflower, Tallahatchie, Tate, Tunica, Warren, Washington and Yazoo.